Friday, 5 June 2026

Elevated microbially-derived metabolites in autism: a possible diagnostic screening test for a distinct ASD phenotype

A quick entry to note that a new paper which yours truly had a small role to play in has been recently published: https://www.nature.com/articles/s41380-026-03620-5

There's been some media around it e.g. https://nypost.com/2026/05/27/health/new-urine-test-could-diagnose-autism-in-children-study/ and how after several years of collaborative research, some potentially important findings in relation to gut bacterial metabolites present in urine *might* be important to some autisms. I've stressed *might* because there's still more to do in this area and indeed, work is still continuing.

There's a couple of things that are standout in the new paper including (i) how mass spectrometry really is a top-notch method in relation to the science of metabolomics https://pharmaceutical-journal.com/article/research/in-search-of-biomarkers-the-science-of-metabolomics-in-pharmacy (particularly when one more than system are independently at work), (ii) gut and yeast related metabolites present in urine are detectable and potentially quite important to some autisms and perhaps beyond as part of that gut-brain axis, and (iii) the Easter egg in the paper was around how some autisms seemed to be linked to various previously undetected inborn errors of metabolism (most screens of IEM via the baby blood spot measurement are done with mass spectrometry too).

I'm not going to bore you with the details particularly when the rather fantastic Dr Jim Adams is going to be hosting a talk about it in the coming days - register here: https://us06web.zoom.us/webinar/register/3617798965724/WN_RBm7QCaFRceTq1EjU8HFsQ#/registration If you're so inclined, register and have a watch.


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