Friday, 26 September 2014

Schizophrenia after child and adolescent psychiatric disorders

More of a 'bring to your attention' post today, as I bring to your attention(!) the paper by Cecilie Frejstrup Maibing and colleagues [1] who concluded: "The risk of being diagnosed with schizophrenia spectrum disorders [SSD] after a child and adolescent psychiatric disorder was significantly increased particularly in the short term but also in the long-term period".
"I coulda been a contender"

The findings were based on an analysis of one of those very informative Scandinavian registries - based in Denmark - which initially identified over 25,000 people born between 1990-2000 diagnosed "with child and adolescent psychiatric disorders". Some 1200 of these people were subsequently diagnosed with schizophrenia spectrum disorders leading to the various conclusions and statistics being produced including: "The risk of schizophrenia spectrum disorders was highly elevated, particularly within the first year after onset of the child and adolescent psychiatric disorder, and remained significantly elevated >5 years with an incidence rate ratio of 4.93". Further: "among persons diagnosed with a child and adolescent psychiatric disorder between the ages 0-13 years and 14-17 years, 1.68% and 8.74 %, respectively, will be diagnosed with a schizophrenia spectrum disorder <8 years after onset of the child and adolescent psychiatric disorder".

With my autism research blogging hat on, and without hopefully making too many sweeping generalisations, I found the Maibing research to be rather interesting. I've previously talked about spectrums colliding on this blog (see here) with specific reference to the work of Kenneth Gadow [2] for example, on "an interrelation between ASD [autism spectrum disorder] and SSD symptoms". That and a post on 'labels and lumping' (see here) affirms that there may indeed be common ground between some of the spectrums, which I might add, are probably plural spectrums [3] (see my take here). As per other research on the possibility of Asperger syndrome in first-episode psychosis (see here), diagnostic vigilance seems to be a key point to take from the Maibing work, and that appears to extend well beyond just what happens after a diagnosis of autism is received...

So, Golden Touch by Razorlight.

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[1] Maibing CF. et al. Risk of Schizophrenia Increases After All Child and Adolescent Psychiatric Disorders: A Nationwide Study. Schizophr Bull. 2014 Sep 5. pii: sbu119.

[2] Gadow KD. Schizophrenia spectrum and attention-deficit/hyperactivity disorder symptoms in autism spectrum disorder and controls. J Am Acad Child Adolesc Psychiatry. 2012 Oct;51(10):1076-84.

[3] Arnedo J. et al. Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies. Am J Psychiatry. 2014. September 15.

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ResearchBlogging.org Maibing CF, Pedersen CB, Benros ME, Mortensen PB, Dalsgaard S, & Nordentoft M (2014). Risk of Schizophrenia Increases After All Child and Adolescent Psychiatric Disorders: A Nationwide Study. Schizophrenia bulletin PMID: 25193974