tag:blogger.com,1999:blog-5548560205914833324.post2524104789131571772..comments2023-04-23T00:16:48.148+01:00Comments on Questioning Answers: Labels and lumping: is autism common in schizophrenia?Paul Whiteleyhttp://www.blogger.com/profile/14288851488012254897noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-5548560205914833324.post-59673388255702016472012-03-28T21:34:20.174+01:002012-03-28T21:34:20.174+01:00Yes, that's the one!Yes, that's the one!David Mosshttps://www.blogger.com/profile/08508780038542342811noreply@blogger.comtag:blogger.com,1999:blog-5548560205914833324.post-36069143815161722792012-03-28T13:02:06.792+01:002012-03-28T13:02:06.792+01:00Thanks for the comment and link David.
Could it ...Thanks for the comment and link David. <br /><br />Could it be Christopher Badcock who you are referring to about the autism - schizophrenia opposites argument?<br /><br />The Crespi paper is interesting in that it looked comparatively at copy number variations (CNVs) between autism and schizophrenia. One flaw in their logic however is the assumption that those CNVs were in fact related to symptoms / syndromes at all, given that irrespective of diagnosis or not, we all carry quite a lot of mutation anyway and there is the very messy factor of comorbidity to take account of. I would also throw in a comment about epigenetic and gene function over gene structure...<br /><br />That and their sweeping generalisation about head growth and autism (which may apply to a sub-group but by no means is a universal phenomenon): http://questioning-answers.blogspot.co.uk/2011/07/head-size-in-autism-is-complicated.html perhaps oversimplifies how the two conditions are related or not.<br /><br />On balance, I am leaning towards a more tapestry view of autism and schizophrenia over a spectrum or diametric model. A tapestry where symptoms overlap and are modified by factors like age, maturation, comorbidity and environment; where hard and fast rules on this or that might not necessarily apply.Paul Whiteleyhttps://www.blogger.com/profile/14288851488012254897noreply@blogger.comtag:blogger.com,1999:blog-5548560205914833324.post-34499940554968231382012-03-28T12:33:46.309+01:002012-03-28T12:33:46.309+01:00How does this relate to the theory that autisma an...How does this relate to the theory that autisma and schizophrenia are *opposite* ends of a spectrum? http://www.newscientist.com/article/dn18226-autism-and-schizophrenia-could-be-genetic-opposites.html (referred to there, I don't remember where I read about it originally).David Mosshttps://www.blogger.com/profile/08508780038542342811noreply@blogger.comtag:blogger.com,1999:blog-5548560205914833324.post-55167635170121018512012-03-26T13:43:06.127+01:002012-03-26T13:43:06.127+01:00Many thanks RAJ.
The DSM-5 proposals for schizop...Many thanks RAJ. <br /><br />The DSM-5 proposals for schizophrenia in cases of autism are interesting. Just looking though the DSM-5 proposal for Asperger syndrome:<br />http://www.dsm5.org/ProposedRevisions/Pages/proposedrevision.aspx?rid=97#<br />It appears that with the suggestion of removing AS as a discrete entity, reference to schizophrenia being an exclusionary diagnosis for consideration BEFORE the proposed autism spectrum is diagnosed also goes bearing in mind chronological age and where a person sits on the suggested autism spectrum. Exactly what this will mean for schizophrenia, the numbers, remains to be seen. <br /><br />I agree about the symptom overlap and have covered that in a recent post on the broader autism phenotype: http://questioning-answers.blogspot.co.uk/2012/03/on-broader-autism-phenotype.html<br /><br />Without getting too philosophical (and political!), the proposed revisions to DSM-5 are, I think, trying to play to two masters: (1) they are trying to fulfill a diagnostic role in terms of labels and the appropriate provisions offered to those with the diagnosis, but I feel that they are also (2) trying to aid a research agenda based on the allocation of a spectrum derived from presentation on the dyad. <br /><br />Exactly how long it will be after these provisions come into effect (which it is increasingly looking like they will) we start to see words like autism SC1RI1 (social communication = level 1, restricted interests = level 1) and other diagnostic variants popping up in research papers is going to be interesting. The questions are whether serving two masters is (a) possible and (b) desirable.Paul Whiteleyhttps://www.blogger.com/profile/14288851488012254897noreply@blogger.comtag:blogger.com,1999:blog-5548560205914833324.post-7748902087557280012012-03-26T13:18:00.441+01:002012-03-26T13:18:00.441+01:00PS. Most children with intellectual disability, co...PS. Most children with intellectual disability, communication disorders, eating disorders even children who may be quiet unassuming and reserved may also have problems with social interaction, communication difficulties or repetitive problems. Autism has always come under the domain of child psychiatrists or psychologists and as such they focus almost exclusively on the behaviors rather than the biology.RAJhttps://www.blogger.com/profile/17686665037607780553noreply@blogger.comtag:blogger.com,1999:blog-5548560205914833324.post-80115061991050791462012-03-26T12:54:23.953+01:002012-03-26T12:54:23.953+01:00Here is the DSM5 working group on schizophrenia pr...Here is the DSM5 working group on schizophrenia proposed new diagnostic criteria for schizophrenia with a comment on the presence or absence of ASD:<br /><br />http://www.dsm5.org/ProposedRevisions/Pages/proposedrevision.aspx?rid=411<br /><br />'F. Relationship to a Pervasive Developmental Disorder: If there is a history of Autistic Disorder or another Pervasive Developmental Disorder or other communication disorder of childhood onset, the additional diagnosis of Schizophrenia is made only if prominent delusions or hallucinations are also present for at least a month (or less if successfully treated).'<br /><br />Prominent delusions or hallucinations are not a feature usually present in autism. The autism spectrum questionaire is not a diagnostic tool for autism. It is a personality questionnaire. Plomin's group in the UK applied the ASQ to thousands of twin pairs recruited from the the Twins Early Developmental Study (TEDS) and reported that 10% of all general population children are positive for high ASQ scores. Obviously, if 10% of all general population children are positive for what some now call Autism Spectrum Condition, psychiatrists have broadend the concept of autism spectrum disorders and schizophrenia spectrum disorders to the point of being almost meaninglessness.<br /><br />“Around 10% of all children showed only social impairment, only communicative difficulties or only rigid and repetitive interests and behavior, and these problems appeared to be at a level of severity comparable to that found in children with diagnosed ASD in our sample ( Happe Arnold et al )”.<br /><br />http://dept.wofford.edu/neuroscience/neuroseminar/pdfFall2011/4-explaining-autism.pdfRAJhttps://www.blogger.com/profile/17686665037607780553noreply@blogger.com