tag:blogger.com,1999:blog-5548560205914833324.post2481902675990260166..comments2023-04-23T00:16:48.148+01:00Comments on Questioning Answers: Glutathione and autism reloadedPaul Whiteleyhttp://www.blogger.com/profile/14288851488012254897noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-5548560205914833324.post-15983553798488188792018-11-09T11:14:43.670+00:002018-11-09T11:14:43.670+00:00I am Prof. AFAF ElAnsary , senior scientist , Cent...I am Prof. AFAF ElAnsary , senior scientist , Central Laboratory , King Saud University Anonymoushttps://www.blogger.com/profile/11517535878186886248noreply@blogger.comtag:blogger.com,1999:blog-5548560205914833324.post-31795978231621430552018-11-09T11:12:57.073+00:002018-11-09T11:12:57.073+00:00Hi
It was very interesting to read this post. I am...Hi<br />It was very interesting to read this post. I am working since 2008 on biomarkers of Autism. It is clear that GSH/ GSSG is greatly affected but my question is: Do you think that only autism demonstrates impaired glutathione homeostasis? The answer is no, most of the chronic neurological diseases show this as metabolic market. I think that due to the complexity of the brain, each disorder must have a panel of biomarkers related different etiological mechanism to each other I.e oxidative stress, glutamate excitotoxicity, neuroinflammation, mitochondrial dysfunctions, and impaired gut microbiota. When we reach this panel then it will be very promising and we can think about biomarkers directed strategies to treat autism.<br />Anonymoushttps://www.blogger.com/profile/11517535878186886248noreply@blogger.comtag:blogger.com,1999:blog-5548560205914833324.post-824629073612000392012-04-25T14:47:06.130+01:002012-04-25T14:47:06.130+01:00Many thanks pD.
It's true what they say abou...Many thanks pD. <br /><br />It's true what they say about waiting for buses (none for hours and lots come along at once). <br /><br />I would think that this and the collected research of the Main review paper should be ample evidence for the initiation of some large scale investigations on GSH and relations in autism and the possibility of a similarly large double-blind, placebo-controlled, cross-over trial to test any effect?Paul Whiteleyhttps://www.blogger.com/profile/14288851488012254897noreply@blogger.comtag:blogger.com,1999:blog-5548560205914833324.post-82647717602639012812012-04-25T14:09:14.348+01:002012-04-25T14:09:14.348+01:00Hot off the presses just in time for your post
Br...Hot off the presses just in time for your post<br /><br /><i>Brain Region-Specific Glutathione Redox Imbalance in Autism</i><br /><br /><i>Autism is a heterogeneous, behaviorally defined neurodevelopmental disorder. Recently, we reported a brain region-specific increase in lipid peroxidation, and deficits in mitochondrial electron transport chain complexes in autism, suggesting the role of oxidative stress and mitochondrial dysfunction in the pathophysiology of autism. However, the antioxidant status of the brain is not known in autism. Glutathione is a major endogenous antioxidant that plays a crucial role in protecting cells from exogenous and endogenous toxins, particularly in the central nervous system. The present study examines the concentrations of glutathione (GSH, reduced form; and GSSG, oxidized form) and the redox ratio of GSH to GSSG (marker of oxidative stress) in different regions of brains from autistic subjects and age-matched control subjects. In the cerebellum and temporal cortex from subjects with autism, GSH levels were significantly decreased by 34.2 and 44.6 %, with a concomitant increase in the levels of GSSG by 38.2 and 45.5 %, respectively, as compared to the control group. There was also a significant decrease in the levels of total GSH (tGSH) by 32.9 % in the cerebellum, and by 43.1 % in the temporal cortex of subjects with autism. In contrast, there was no significant change in GSH, GSSG and tGSH levels in the frontal, parietal and occipital cortices in autism versus control group. The redox ratio of GSH to GSSG was also significantly decreased by 52.8 % in the cerebellum and by 60.8 % in the temporal cortex of subjects with autism, suggesting glutathione redox imbalance in the brain of individuals with autism. These findings indicate that autism is associated with deficits in glutathione antioxidant defense in selective regions of the brain. We suggest that disturbances in brain glutathione homeostasis may contribute to oxidative stress, immune dysfunction and apoptosis, particularly in the cerebellum and temporal lobe, and may lead to neurodevelopmental abnormalities in autism.</i><br /><br />Interesting. . . .passionlessDronehttps://www.blogger.com/profile/05398721312156704738noreply@blogger.com